Photochemical and Photobiological Properties of New Bispsoralen Derivatives (Bis[PsCn]PIP, n = 4, 6, 8)¶

Sung Ki Kim; Han Oh Park; Sang Chul Shim

doi:10.1562/0031-8655(2000)072<0472:PAPPON>2.0.CO;2

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Sung Ki Kim,¹ Han Oh Park,² Sang Chul Shim^3,*

¹aDepartment of Chemistry, School of Molecular Science and Center for Molecular Design and Synthesis,
²bBiological Research Center in Bioneer Co., Namee-Myoun, Cheongwon-Gun, Chungcheongbuk-Do, South Kor
³dDepartment of Chemistry, School of Molecular Science and Center for Molecular Design and Synthesis,

^*¶Posted on the website 8 August 2000.*To whom correspondence should be addressed at: Department of Chemistry, School of Molecular Science and Center for Molecular Design and Synthesis, Korea Advanced Institute of Science and Technology, 373-1 Kusung-Dong, Yusung-Gu, Taejon 305-701, South Korea. Fax: 82-42-869-2810; scshim@mail.kaist.ac.kr

Abstract

Bispsoralen derivatives possessing two psoralens and one piperazine molecule, 1,4-bis[n′-(8-psoralenoxy) alkyl] piperazine (Bis[PsC_n]PIP, n = 4, 6, 8), show high water solubility, efficient intercalation into DNA and good photocrosslinking efficiency of DNA. Bis(PsC₄)PIP shows high lethality on bacteriophage T7 and can effectively inhibit the amplification of DNA by stopping the polymerase chain reactions in a short period of irradiation time.

Citation Download Citation

Sung Ki Kim, Han Oh Park, and Sang Chul Shim "Photochemical and Photobiological Properties of New Bispsoralen Derivatives (Bis[PsC_n]PIP, n = 4, 6, 8)^¶," Photochemistry and Photobiology 72(4), 472-476, (1 October 2000). https://doi.org/10.1562/0031-8655(2000)072<0472:PAPPON>2.0.CO;2

Received: 25 May 2000; Accepted: 1 July 2000; Published: 1 October 2000

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